The 23-year-old replaced John Stones just after the hour-mark at Wembley, as the Three Lions earned a first home victory over Italy since 1977, winning out 3-1.
The three points mean Gareth Southgate’s side have qualified for the European Championships in Germany next summer.
Palace No. 1 Sam Johnstone was an unused substitute, having earned his fourth England cap, and first in over two years, as he started and kept a clean sheet in England's 1-0 friendly win over Australia on Friday night.
The goalkeeper made one particularly brilliant first-half save from Keanu Baccus, along with several other smart stops, to preserve his impressive record of never having conceded a goal for the Three Lions' senior side.
Joachim Andersen’s Denmark could be joining England at the Euros, as they beat San Marino away from home by a 2-1 scoreline to ensure at least a play-off spot and likely secure qualification; the Palace man played the full 90 minutes.
The previous week, Andersen continued his productive attacking form this season with his third assist for his country in a 3-1 win over Kazakhstan in Copenhagen.
With Denmark aware that three points would put them on the cusp of qualification, Andersen got the ball rolling for his side on 36 minutes, heading Christian Eriksen's floated free-kick back across goal for Jonas Wind to turn in.
Should Denmark beat either Slovenia at home or Northern Ireland away next month, they will secure qualification; a point against either side is likely to be enough, however.
In friendly action, Chris Richards and Jordan Ayew faced one another in Nashville as the United States beat Ghana 4-0. Both Palace men started the game, with the former substituted late on and the latter playing the full 90 minutes. Richards earned his 14th cap and Ayew took his personal tally to 93.
It capped a busy break for Richards, who featured in a tight defeat to Germany in Connecticut on Saturday night. The United States took the lead inside half-an-hour through Christian Pulisic, but could not prevent a German fightback in the second-half before the Palace defender was replaced on 65 minutes.
Ayew's trip across the pond began by featuring late on for Ghana in a friendly defeat to Mexico in North Carolina in the small hours of Sunday morning. The Palace attacker came on for the final 20 minutes of the match but, with his side trailing 2-0 at that stage, could not alter the course of the game.
Find a full recap of all the results from Palace's international Eagles below...
Denmark – Andersen
- Sat, 14th October: Denmark 3-1 Kazakhstan (Andersen played 90 minutes and assisted Jonas Wind's opening goal)
- Tue, 17th October: San Marino 1-2 Denmark (Andersen played the full 90 minutes of an important away win)
England – Guéhi and Johnstone
- Fri, 13th October: England 1-0 Australia (Johnstone kept his fourth clean sheet in four England games; Guéhi was an unused substitute)
- Tue, 17th October: England 3-1 Italy (Guéhi came on after 63 minutes; Johnstone was an unused substitute)
Ghana – Ayew
- Sun, 15th October: Mexico 2-0 Ghana (Ayew played the final 20 minutes of the defeat in North Carolina)
- Wed, 18th October: United States 4-0 Ghana (Ayew played the full 90 minutes)
United States – Richards
- Sat, 14th October: United States 1-3 Germany (Richards played the first 65 minutes of the eventual defeat in Connecticut)
- Wed, 18th October: United States 4-0 Ghana (Richards started, playing 72 minutes)