The Ghanaian begins up front for Palace at Molineux searching for his first goal for the club since his summer loan move from Swansea City, with Wilfried Zaha and Andros Townsend supporting him in attack and Jeffrey Schlupp dropping out of the starting XI to accommodate Ayew.
There are no other alterations to the Eagles' team from the weekend, although Schlupp, Jairo Riedewald and Martin Kelly are named on the bench.
Wolves meanwhile have made three changes from the team that beat Tottenham Hotspur 3-1 at Wembley four days ago, with Joao Moutinho recalled and Ruben Neves dropping to the bench.
Romain Saiss replaces Leander Dendonker while Adama Traore is demoted to the substitutes with Helder Costa handed a start instead after he netted against Spurs.
Wolves: Patricio, Coady, Boly, Bennett, Doherty, Moutinho, Saiss, Jonny, Costa, Cavaleiro, Jimenez. Subs: Ruddy, Vinagre, Dendonker, Gibbs-White, Neves, Traore, Bonatini.
Palace: Guaita, Wan-Bissaka, Tomkins, Sakho, Van Aanholt, McArthur, Milivojevic, Kouyaté, Townsend, Zaha, Ayew. Subs: Hennessey, Ward, Kelly, Riedewald, Schlupp, Meyer, Wickham.