The manager has made two changes to his starting XI, with Chalobah starting alongside Marc Guéhi and Maxence Lacroix at the back, with Jefferson Lerma moving into midfield; Daichi Kamada drops to the bench.
In attack, Sarr starts for the first time alongside Ebere Eze and Eddie Nketiah, with Jean-Philippe Mateta among the substitutes.
There are opportunities in the matchday squad for two Academy prospects, with Franco Umeh and defender Caleb Kporha on the bench - find out more about Kporha HERE.
Palace: Henderson (GK), Muñoz, Lacroix, Guéhi, Chalobah, Mitchell, Lerma, Wharton, Sarr, Eze, Nketiah.
Subs: Turner (GK), Ward, Clyne, Kporha, Hughes, Schlupp, Kamada, Umeh, Mateta.
Liverpool: Alisson (GK), Alexander-Arnold, Van Dijk, Konate, Tsimikas, Gravenberch, Jones, Mac Allister, Gakpo, Jota, Salah.
Subs: Jaros (GK), Gomez, Quansah, Robertson, Bradley, Endo, Szoboszlai, Diaz, Nunez.