Mitchell lines up in defence alongside Joachim Andersen, Marc Guéhi and Nathaniel Clyne, with Cheick Doucouré and Jeffrey Schlupp ahead of them – the latter replaces Will Hughes.
In attack, Jordan Ayew leads the line with Michael Olise and Wilfried Zaha on either side; Ebere Eze replaces Odsonne Edouard.
Edouard is available from the bench alongside Jean-Philippe Mateta, while 17-year-old David Ozoh is also among the replacements.
Chelsea: Arrizabalaga, Badiashile, Mukinayi, Jorginho, Silva, Chalobah, Mount, Ziyech, Gallagher, Havertz, Chukwuemeka, Hall.
Subs: Bettinelli (GK), Kovacic, Aubameyang, Loftus-Cheek, Koulibaly, Fofana, Azpilicueta, Cucurella, Humphreys.
Palace: Guaita (GK), Clyne, Guéhi, Andersen, Mitchell, Doucouré, Schlupp, Zaha, Eze, Olise, Ayew.
Subs: Johnstone (GK), Ward, Milivojevic, Tomkins, Mateta, Hughes, Edouard, Richards, Ozoh.