The Palace midfielder opened the scoring within minutes of coming on, latching on to Michael Olise’s delightful delivery to head home.
Eze's impact saw him earn 26.8% of the votes, narrowly pipping Joachim Andersen (25.6%) into second place.
Andersen returned to the defence for the first time since his injury at Stamford Bridge, and was his assured self against one of the league's in-form attackers in Ivan Toney.
Olise, who provided the assist, came in third with 16%.
Check out the full results for Mukuru’s Man of the Match award in the poll.