But Palace continued to scrap and got themselves back in the game in superb fashion, Clyne picking out fellow substitute Eddie Nketiah, who headed home a wonderful goal at his former stomping ground – his second goal in the competition this season.
The Eagles threw everything at it for the final ten minutes, but after one final corner-kick was cleared the full-time whistle arrived.
The result ends Palace’s interest in the Carabao Cup, but the team put in a brave performance and on another night with the luck on their side would have prevailed.
Arsenal: Raya (GK), Partey (Saliba, HT), Timber, Kiwior (Gabriel, 86), Tierney (Lewis-Skelly, 69) Jorginho, Merino, Nwaneri (Odegaard, 46), Sterling (Saka 69), Trossard, Jesus
Subs: Setford (GK), Kacurri, Martinelli, Havertz
Palace: Henderson (GK), Kporha (Clyne, HT), Guehi, Lacroix, Chalobah, Mitchell (Schlupp, 86), Lerma, Hughes (Devenny, 80), Eze (Kamada, 59), Sarr, Mateta (Nketiah, 59)
Subs: Turner (GK), Ward, Richards, Doucoure
As It Happened: