Palace Women dominated early proceedings as they looked to make it two wins over London City Lionesses in four days.
And it took Elise Hughes just 15 minutes to score her 20th goal of the 2023/24 campaign. Fliss Gibbons' cross found Araya Dennis inside the box, who flicked the ball into Hughes – who slotted it coolly between the keeper’s legs.
Another Gibbons ball caused trouble inside the home box in the 33rd minute, as the ball fell to Hughes, but her effort was pushed around the post by the 'keeper.
Anna Filbey floated the follow up corner kick into the area for Aimee Everett to fire towards goal but her strike was blocked before it was able to test the keeper.
Palace were unable to replicate their first-half dominance and form and found themselves on the back foot on the 57th as Chantelle Boye-Hlorkah levelled the score with a thundering 25 yard strike.
Boye-Hlorkah bagged her second of the game seven minutes later as she put the home side ahead for the first time that evening.
Palace immediately went on the hunt for the equaliser and came close on the 73rd as a cross from Isabella Sibley fell to Molly Sharpe inside the box but her first time shot was well held.
Sibley found Dennis inside the area minutes from time, and the youngster rose high to meet the ball, but she could only guide her header wide of the target.
Substitute Paige Bailey-Gayle thought she had netted the leveller three minutes into stoppage time, as she rifled the ball into the back of the net after picking up a pass from Shanade Hopcroft, but the linesman raised her offside flag to disallow the strike – despite her appearing onside.
Palace: Negri, Cataldo, Johnson, Everett (Nolan, 46), Gibbons (Sharpe, 46), Arthur (Potter, 70), Filbey (Hopcroft, 70), Sibley, Guyatt, Dennis, Hughes (Bailey-Gayle, 46)
Subs: Lambourne
London City Lionesses: Cull, Farrelly, Brougham, Mukandi, Cowan, Joel, Groves, Alexander (Wilde, 79), Carter, Boye-Hlorkah (Neville, 90+4), Douglas (Fitzgerald, 79)
Subs: Uttridge, Scofield, Culver, Littlejohn