The Ghanaian comes in for Max Meyer who started Monday night’s game against Bournemouth, with the German dropping to the bench.
Wolves meanwhile have once again named the same team for the eighth successive league game, with Helder Costa fit to start having been doubtful earlier in the week after picking up a knock in their 2-0 win against Southampton last week.
That is a bonus for Nuno Espirito Santo’s team who are looking to stretch their five-game unbeaten run.
Palace: Hennessey, Wan-Bissaka, Tomkins, Sakho, Van Aanholt, Schlupp, McArthur, Milivojevic, Townsend, Zaha, Ayew. Subs: Guaita, Ward, Kelly, Puncheon, Kouyaté, Meyer, Sørloth.
Wolves: Patricio, Bennett, Coady, Bolly, Doherty, Moutinho, Neves, Jonny, Jota, Costa, Jimenez. Subs: Ruddy, Hause, Saiss, Gibbs-White, Traore, Bonatini, Cavaleiro.
You can listen to full commentary of this game live on Palace Audio for just £1.49 - details.