The duo replace Jairo Riedewald and Wilfried Zaha in the Palace side, who are aiming to become the first team to win four consecutive top-flight games at Anfield since 1935 and bounce back from last weekend’s 3-0 loss to Huddersfield Town.
Meanwhile, James McArthur and Yohan Cabaye have been named on the bench after featuring in Monday’s development league game against Burnley.
Having named an unchanged line-up for both of Liverpool’s games against Watford and Hoffenheim in the past week, Jurgen Klopp has made five alterations and handed Andrew Robertson a Reds debut in defence.
He replaces Trent Alexander-Arnold, while Ragnar Klavan and Joe Gomez are preferred to Dejan Lovren and Alberto Moreno in a big defensive reshuffle, with only Joel Matip surviving.
Summer recruit Mohamed Salah also drops to the bench with Daniel Sturridge replacing him in attack, and James Milner gets the nod ahead of Emre Can.
Liverpool: Mignolet, Robertson, Klavan, Matip, Gomez, Wijnaldum, Henderson, Milner, Mane, Firmino, Sturridge. Subs: Karius, Flanagan, Lovren, Can, Salah, Origi, Solanke.
Palace: Hennessey, Ward, Tomkins, Dann, Fosu-Mensah, Van Aanholt, Loftus-Cheek, Puncheon, Milivojevic, Townsend, Benteke. Subs: Speroni, Schlupp, Kelly, Cabaye, McArthur, Lokilo, Kaikai.