The game will take place at the VBS Community Stadium in Sutton, with tickets still available here.
The Eagles – who won 6-0 against Chatham Town to reach this stage last month – will be looking to go further than last season, when they defeated Watford 5-1 in the third round, but fell in the fourth away to Durham.
Doing so would also be a historic feat for Palace Women since turning semi-professional.
Blackburn, meanwhile, play in the Women’s Championship alongside Palace, and currently sit seventh in the table with five wins from 10 matches. The Eagles ran out 4-0 winners when the two sides met at Ewood Park in October.
Supporters not in south London can tune in to watch LIVE and FREE on Palace TV; you need only register and login to your Palace account to watch.
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Supporter information
Matchday at Sutton will once again offer up plenty of family-friendly fun, with indoor activities and the opportunity to meet the players at the end of the game. Turnstiles will open at 12:00 GMT.
Tickets are also available on the gate – although prices are discounted if booked online (even if booked on-the-day) via cpfc.co.uk. Prices will increase when purchased at the stadium.
Tickets will be sent to supporters 48 hours before the match. You will be able to view your purchase in your account history on the ticket website within your Palace account.
Please note that home matches in the Adobe Women's FA Cup are not included in 23/24 Women's season tickets.