The Eagles have senior team goalkeeper, Stephen Henderson, between the sticks, whilst Nya Kirby, Gio McGregor and James Daly all start - the trio will be hoping their experience with the first-team matchday squads in recent weeks will put them in good stead for the 90 minutes ahead.
Derry has awarded Dion Woodman and Cameron Jessup, both players for the Under-18s, with spots on the bench.
Charlton's lineup includes two first-teamers returning from injury: Ben Amos and Lewis Page.
Palace: Henderson, Rich-Baghuelou, Hobbs, Mensah, Mitchell, Trialist, McGregor, Kirby, Trialist, Lokilo, Daly.
Subs: Woodman, Webber, Jessup, Ajayi, Trialist.
Charlton: Amos, Stevenson, Yao, Keefe, Page, Vennings, Quitirna, Wiredu, Powell, Odoh, Isiaka.
Subs: Osaghae, Maloney, Clayden, Ocran.