Palace led 2-0 at half-time with goals from John-Kymani Gordon and Tyrick Mitchell before pulling away with the game through Kian Flanagan and a Tafari Moore own goal.
The match began at breakneck pace and chances continued to rain throughout the clash. Colchester earned a consolation goal when Jake Hutchinson struck from the spot and the converted penalty inspired a resurgent finish from the U's, which Palace's defence did well to battle off.
In the highlights below, you can see how Mamadou managed and all of the game's six goals!