Emma Hayes' Blues team, all-conquering in domestic competitions in recent seasons, will form Palace's showpiece fifth-round opposition.
The match will take place at Kingsmeadow on Sunday 11th February, kicking off at 14:00 GMT.
The Eagles have reached this stage having won back-to-back matches in the competition for the first time since turning semi-professional: 6-0 against Chatham Town last month in the third round, and 3-1 against Blackburn Rovers in the fourth.
The Eagles have reached the fifth round on two occasions in the last five seasons: in 2020/21, when they were eliminated by titans Arsenal, having overcome London Bees in the fourth round; and in 2019/20, when Palace defeated Southampton Women’s FC but were felled by top-flight Brighton & Hove Albion.
Chelsea have finished as Women's Super League champions in each of the last four seasons, and have won the FA Cup in the last three – including a 1-0 win over Manchester United at Wembley last May.
They go into the match at the peak of the top-flight table, having scored 41 times in 13 matches, and in the hunt for a quadruple in Emma Hayes' final season.
Palace's test, simply put, could not be sterner – but those kinds of circumstances quite often produce the most incredible of memories.
Broadcast details
The match will be broadcast live on the FA Player and the @adobewomensfacup social channels (X/Twitter, Facebook and TikTok).
Ticket Details
Supporters are advised to call the Palace box office on 0333 360 1861 (press option 1) to purchase and arrange collection (please note this will need to take place before 17:30 on Saturday). Away tickets for this match are on sale, but will close via the club at 17:00 GMT on Saturday (10th February).
After this point, Chelsea will be selling tickets on the day and their stadium is unsegregated, so tickets can be purchased at Kingsmeadow.
There will be a dedicated away section in the North Stand of the ground, and we have taken an increased allocation for this fixture.
Tickets are limited to two tickets per person. There is a designated singing section at the back of the stand – to purchase tickets in the singing section, please call the box office on 0333 360 1861.
To purchase accessible tickets, please also call the box office.
Please note that no unaccompanied Under-16s will be admitted into Kingsmeadow.