Blackburn play in the Women’s Championship alongside Palace, and currently sit sixth in the table with five wins from 10 matches.
The Eagles ran out 4-0 winners when the two sides met at Ewood Park in October.
Palace will face Blackburn on Sunday 14th January 2023, with kick-off time, ticketing and potential broadcast details to be announced in due course.
The fourth-round draw also saw top-flight teams will enter the competition for the first time.
The Eagles will be looking to go further than last season, when they defeated Watford 5-1 in the third round, but fell in the fourth away at Durham.
Stay tuned to cpfc.co.uk, the official App and across our social media channels for confirmed ticketing and potential broadcast details.